While Rituximab has increased survival in CLL patients, it has adverse effects including (1) reduced immunoglobulin levels and (2) increased risk of certain infections. Discuss the underlying mechanisms of these adverse effects in patients receiving rituximab-based therapies.
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- propose a biomaterial-based drug delivery system for carrying targeted delivery of doxorubicin for the specific treatment of hepatocellular carcinoma via intravenous route (for human)Pharmacology of Anti-TB Drugs Objective: To discuss the pharmacology of individual anti-TB medication in terms of: а. Mechanism of action b. Pharmacokinetics C. Contraindications, Warnings and Precautions d. Adverse effects e. Drug Interaction Instruction: 1. Answer the stated objectives using the following drugs. Rifampicin Pyrazinamide Ethambutol StreptomycinPharmacology of Anti-TB Drugs Objective: To discuss the pharmacology of individual anti-TB medication in terms of: a. Mechanism of action b. Pharmacokinetics Contraindications, Warnings and Precautions d. Adverse effects e. Drug Interaction C. Instruction: 1. Answer the stated objectives using the following drugs. a. Isoniazid b. Rifampicin c. Pyrazinamide d. Ethambutol e. Streptomycin
- Mrs. Anderson, a 45-year-old woman with a history of chronic back pain, has been taking X as prescribed by her rheumatologist for the past eight months. During a routine check-up, her liver function tests revealed significantly elevated liver enzymes. She has not experienced any noticeable symptoms but is now being closely monitored for potential liver-related issues. 1. Define the concept of signal detection in pharmacoepidemiology and explain its role in identifying potential adverse drug reactions. Discuss the importance of signal detection in ensuring the safety of pharmaceutical products in the post-marketing phase. 2. Propose a pharmacoepidemiological study design to confirm or refute the signal of hepatotoxicity associated with X. Consider factors such as study population, exposure definition, and outcome measures. Discuss the strengths and limitations of your chosen study design. 3. Outline the methods and data sources that could be used to collect information on…Many adults and older adults use aspirin daily for antiplatelet benefits. What nursing considerations are essentials when working with these patients? What teaching points are important for patients on antiplatelet therapy?Briefly explain this statement -"Therapeutic drug monitoring of Warfarin" Please explain at your own words(500-600 words appropriately).
- Reviewing drug characteristics, choose an antimicrobial for each of the following situations (explain your choice): a. for an adult patient suffering from Mycoplasma pneumonia b. for a child with bacterial meningitis (drug must enter into cerebrospinal fl uid) c. for a patient who has chlamydiosis and an allergy to azithromycin d. for treating a child with Rocky Mountain spotted fever e. for PPNG drug-resistant gonorrheaA 67 years old female patient. She presented to her GP last week, complaining of a very strong headache, followed by dizziness. The symptoms had resolved by the time she could see the GP, who was concerned enough to request a CT of her head and neck. Diabetes mellitus Type 2: Management: metformin 1000mg, daily enalapril 10 mg daily rosuvastatin 10mg, daily Atrial fibrillation (AF) Management: apixaban 2.5 mg, BD sotalol 40 mg, BD Cigarette smoking: 20 - 30 cigarettes/day, quit 5 years ago. She underwent a CT scan of the head and neck, but the results were normal. the patient was assessed as requiring changes to her hypertension & AF management and the following changes made: enalapril ceased the following medications commenced or changed; irbesartan/ hydrochlorothiazide 300/25, daily amlodipine 5mg, daily apixaban 5mg, BD This morning patient woke up at 0600 hours with a 5/10 headache. At 0700 hours she began to feel weak in her limbs, and her headache increased to…Reviewing drug characteristics, choose an antimicrobial for each ofthe following situations (explain your choice):a. for an adult patient suffering from Mycoplasma pneumoniab. for a child with bacterial meningitis (drug must enter intocerebrospinal fluid) c. for a patient who has chlamydiosis and an allergy to azithromycind. for PPNG drug-resistant gonorrhea