Calculate the ATP yield for the complete oxidation of the ketone body 3-hydroxybutryate to 4 CO2 in the mitochondrial matrix. Use P:O ratios of 2.5 for NADH and 1.5 for QH2. Draw the chemical reaction and the movement of electrons (including the enolate intermediate) necessary for the spontaneous decarboxylation of acetoacetate to acetone and CO2. (Hint: review the mechanism of step 4 in glycolysis and step 3 in the citric acid cycle). Why is acetoacetate undergoing spontaneous decarboxylation while 3-hydroxybutyrate does not?

Calculate the ATP yield for the complete oxidation of the ketone body 3-hydroxybutryate to 4 CO2 in the mitochondrial matrix. Use P:O ratios of 2.5 for NADH and 1.5 for QH2. Draw the chemical reaction and the movement of electrons (including the enolate intermediate) necessary for the spontaneous decarboxylation of acetoacetate to acetone and CO2. (Hint: review the mechanism of step 4 in glycolysis and step 3 in the citric acid cycle). Why is acetoacetate undergoing spontaneous decarboxylation while 3-hydroxybutyrate does not?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter20: Electron Transport And Oxidative Phosphorylation

Section: Chapter Questions

Problem 11P

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