(a)
To determine: The use of Strecker synthesis to make phenylalanine.
Interpretation: The use of Strecker synthesis to make phenylalanine is to be shown.
Concept introduction: Strecker synthesis is a two step procedure that is used to synthesize alpha amino acids from
(b)
To determine: A mechanism for each step in the synthesis in part (a).
Interpretation: A mechanism for each step in the synthesis in part (a) is to be proposed.
Concept introduction: Strecker synthesis is a two step procedure that is used to synthesize alpha amino acids from aldehydes using a metal cyanide, acid catalyst and water. In first step, condensation of ammonia takes place with aldehyde to form an imine. It is followed generally by hydrolysis to
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Organic Chemistry (9th Edition)
- Propose an efficient synthesis N.arrow_forward2. (a) Mark the alpha carbons with "a" and draw out the alpha hydrogens (if any are present). (b) If enolizable, draw a mechanism and the enolate product below. Use B: as a generic base. H₂Narrow_forwardThe following three derivatives of succinimide are anticonvulsants that have found use in the treatment of epilepsy, particularly petit mal seizures. Q. Propose a mechanism for the conversion of (D) to phensuximide.arrow_forward
- Which starting materials will result in the below product through a reductive amination reaction? The correct answer is C, but please explain why:)arrow_forwardWhich ester, C or D, is more reactive in nucleophilic acyl substitution?Explain your reasoning.arrow_forwardB. Give a reasonable synthesis pathway for the transformation below. You may use any organic and inorganic reagents.arrow_forward
- Propose a synthetic route C.arrow_forwardSynthesize the compund (Nifedipine) via Hantzsch dihydropyridine synthesis.arrow_forwardD. Draw stepwise mechanism for the given amide. You can use hydroxybenzotriazole (HOBt) or 1-Hydroxy-7-azabenzotriazole (HOAt) as catalyst. 1 forosos NH₂ Diisopropylcarbodiimide (DIC)arrow_forward
- Propose a synthesis pathway of molecule J on the left using the reagents on the rightarrow_forwardWhich reaction intermediate (A or B) is more likely to form in the epoxide ring opening reaction? Reactions prefer to react through lower energy intermediates. Hint: how might you justify one structure being lower in energy than the other? Draw structures as part of your explanation why. F F. BOH F :0. Br Br Br H H epoxide ring opening Structure A Which alcohol structure shown below would be less acidic? Explain why. OH Structure B : 0. : OHarrow_forwardTo preview image click here ↓ Perform the retrosynthetic analysis for the indicated bond and choose the correct synthetic equivalents. A. B. O A B D : OMe + :0: + NaOMe + NaOMe C. D. MeO +ÖMe + NaOH NaOHarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage LearningOrganic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning