Interpretation:
The absolute configuration
Concept introduction:
A chirality center is the tetrahedral carbon which is directly attached to four different atoms or groups.
In the Fischer projection, the vertical bonds point away from the observer while the horizontal bonds point towards the observer.
When determining the configuration, the molecule is oriented such that the lowest ranked atom points away from the observer.
The order of decreasing priorities of the three other atoms or groups is decided. If it traces a clockwise path, the configuration is R and if it traces a counterclockwise path, the configuration is S.
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Organic Chemistry - Standalone book
- In the Fischer projection below, what are the configurations of the two asymmetric centers? CHs ČH-CH2OH HO 2R, 3S 2S, 3R 2S, 3S 2R, 3R cannot be determined from structurearrow_forwardHO Assign R, S configurations to the chiral centers in the following molecule.arrow_forwardWhich of the following structures is the correct wedge/dash drawing of the following Fischer projection? H Br- Et Br -Br H Br || ||| IV Br Br +x Br Br ||| Br IVarrow_forward
- 6. Each of the following pairs of compounds contains one chirality center. Determine whether they are the same compound or enantiomers. If they are superimposable, they are the same. If they are nonsuperimposable, they are mirror images, they are enantiomers. Br C1 I_CC1 I— H Ме- Me-C Br Et H Br Cl H C-I Me-C Et Br H I-C Br Me BrC-I H H Et-C Br Me Me H H-C Br Me Et 1 2 Sk 954~ Rost 45 r Siarrow_forward5. Consider the following pairs of structures. Identify the relationship between them (enantiomers, diastereomers, or identical compounds. он HO o CH,OH H,C H но CH,OH сон H HO. HO CH, HO,C CH COH HO,C, CO,H CO,H н онн он н онн он HOH,C сно OHC CH,OH Br CH,CH, H,CH,C CI CH OHarrow_forwardDraw Fischer projections for the following compounds and determine whether they are (R) or (S). Br ОН H,C. :C H CH,CH,arrow_forward
- 7) Which of the following terms best describes the pair of compounds shown: enantiomers,_ diastereomers, or the same compound? CH3 H C OH 3arrow_forwardQ5. For each of the following pairs of stereoisomers, indicate if they are enantiomers, diastereomers, or identical compounds. Br Br CH3 Br H3C° H3C° Br CH3arrow_forward6) Which of the following terms best describes the pair of compounds shown: enantiomers, diastereomers, or the same compound? CH3 H- CO₂H NH₂ CO₂OH H+N³H CH3arrow_forward
- For the compound shown below, correctly label the stereogenic centers. O C1 is R; C2 is R O C1 is S; C2 is S C1 is S; C2 is R C1 is R; C2 is Sarrow_forward1. Below is the Fischer projection of a molecule. Is this the (R) or (S) enantiomer? 2. If you swap the positions of the H and the Cl, does this represent the same enantiomer or the opposite one? 3. Having swapped the positions of the H and CI, if you then swap the Cl and methyl group, what happens to the stereochemistry of the chiral center? CH3 H- CI CH,CH3arrow_forwardH- CO₂H CH3 F Select the appropriate stereochemical designation based on the Fischer projection shown above.arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning