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Celiac Disease Case Study

Decent Essays

1. Explain the physiologic mechanisms related to celiac disease. What anatomical features of the small intestine lend it to the digestion and absorption of fats, carbohydrates, and proteins? Celiac disease is an autoimmune disease triggered by ingestion, of gluten-containing foods. The disease results from inappropriate T cells immune response against gliadin in genetically predisposed people. Individuals with this disorder have high levels of antibodies to a variety of antigens. The resulting immune response produces a strong inflammatory reaction that results in loss of absorptive villi from the small intestine. After the subsequent lesions are widespread, they may weaken absorption of macronutrients and micronutrients. Small bowel involvement …show more content…

It contains many circular folds that increase the surface area of the functional mucous membrane. Enterocytes are cells found in the upper part of each villus and secrete enzymes for the digestion and absorption of fats, carbohydrates, and proteins. Not having the villi within the inner surface of small intestine makes the body is unable to absorb nutrients essential for health and growth. Instead, nutrients such as fat, protein, vitamins, and minerals are eliminated in the stool (NIDDK, 2018). 2. Sometimes individuals with celiac disease experience steatorrhea (fatty stools) after eating foods containing gluten. What are the chemical components that normally digest fats in the small intestine, and how are the fats are absorbed? The digestion of lipids occurs mostly in the small intestine, mainly the upper jejunum. Lipases from the pancreas are secreted into the small intestine as a part of pancreatic enzyme and breakdown lipids to fatty acids. Bile salts, created by the liver, enter the duodenum to mix with fatty acids to form micelles. The development of these micelles allows the absorption of fatty acids at intestinal villi. Pancreatic lipase, bile salts and functioning lymphatic channels help break up fat if these are working correctly then steatorrhea

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