1 2 E. Donkey 8. Two independent genes are located near each other on the genome of the mouse. Whiskers is required for formation of whiskers, fur is required for fur formation, assume mutations in these genes are recessive (ie require a homozygous to be no-fur, no whiskers)

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Chapter10: Biotechnology
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5.
7.
3.
E. Donkey
8. Two independent genes are located near each other on the genome of the mouse.
Whiskers is required for formation of whiskers, fur is required for fur formation, assume mutations in these
genes are recessive (ie require a homozygous to be no-fur, no whiskers)
Non-coding region
Non-coding region
Non-coding region
whiskers
1 1
A
B.
C.
a) If you insert an extra nucleotide at position B, what will be the phenotype of an animal homozygous for
(circle one for each: Fur/no fur whiskers/no whiskers)
this mutation?
b) If you insert a nucleotide at position C, what will be the homozygous phenotype?
(circle one for each: Fur/no fur whiskers/no whiskers
c) If you insert a nucleotide at position E, what will be the homozygous phenotype?
(circle one for each: Fur/no fur whiskers/no whiskers )
d) If you insert a nucleotide at position B, and take one away from position C, what will be the
homozygous phenotype?
(circle one for each: Fur/no fur whiskers/no whiskers
e) If you insert a nucleotide at positions A and C, what will be the homozygous phenotype?
(circle one for each: Fur/no fur whiskers/no whiskers
f) If you insert a nucleotide at position A, how might you be able to suppress the mutant phenotype?
g) If you add two nucleotides at position B, name two distinct alterations you could make
at position A that would suppress the phenotype.
9. The following sequence is a wild-type bacterial gene that encodes a short protein. The sequence
F5
F7
F8
F12
61
しゴ
Transcribed Image Text:II O Search entral dogma (3) - Protected View Saved to this PC Mailings Review View Help iruses. Unless you need to edit, it's safer to stay in Protected View. Enable Editing 5. 7. 3. E. Donkey 8. Two independent genes are located near each other on the genome of the mouse. Whiskers is required for formation of whiskers, fur is required for fur formation, assume mutations in these genes are recessive (ie require a homozygous to be no-fur, no whiskers) Non-coding region Non-coding region Non-coding region whiskers 1 1 A B. C. a) If you insert an extra nucleotide at position B, what will be the phenotype of an animal homozygous for (circle one for each: Fur/no fur whiskers/no whiskers) this mutation? b) If you insert a nucleotide at position C, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers c) If you insert a nucleotide at position E, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers ) d) If you insert a nucleotide at position B, and take one away from position C, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers e) If you insert a nucleotide at positions A and C, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers f) If you insert a nucleotide at position A, how might you be able to suppress the mutant phenotype? g) If you add two nucleotides at position B, name two distinct alterations you could make at position A that would suppress the phenotype. 9. The following sequence is a wild-type bacterial gene that encodes a short protein. The sequence F5 F7 F8 F12 61 しゴ
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