14C methyl pyruvate is added isolated liver tissue and malonate is used to break succinate dehydrogenase completely.After some time isocitrate is formed to carry label in carbon 2 and 4. Explain how can this happen

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 20P: Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have...
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14C methyl pyruvate is added isolated liver tissue and malonate is used to break succinate dehydrogenase completely.After some time isocitrate is formed to carry label in carbon 2 and 4. Explain how can this happen

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