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Discuss how Plasmodium falciparum transitions from the salivary glands of the
mosquito to the red blood cells of a human host.
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- Imagine a newly developed drug that is highly lethal against all stages in the life cycle of Toxoplasma gondii. The drug has been found to be safe and effective both for human and for veterinary use. Although the drug can eliminate infection in both humans and cats, its use in humans will have vey little impact on overall prevalence of human toxoplasmosis. Its use in cats, alternatively, could, at least in theory, reduce prevalence in both humans and cats. Explain this difference.Malaria disease is characterized by cycles of symptoms that last 4-8 hours and have 3 stages; a 15-to-60 minute cold stage when you shiver and feel very cold, a 2-6 hour hot stage when your fever may reach as high as 41oC and finally, a 2-4 hour sweating stage during which your fever drops rapidly. These cycles are called paroxysms. Explain why they typically happen in malaria patients based on the pathogen life cycleDifferent strains of Streptococcus pyogenes have different virulence factors, giving these microbes much versatility. Virulence factors include which of the following? Choose one or more: A.A capsule that, when thick, will help the organism avoid phagocytosis by macrophages B.A cell wall containing lipoteichoic acid, thought to facilitate adherence to pharyngeal epithelial cells C.Enzymes that lyse blood cells (streptolysins) D.The production of several endotoxins called streptococcal pyogenic endotoxins (SPEs)
- Pseudomonas aeruginosa can cause disease in immunocompromised people. What are two characteristics - either epidemiological or part of its biology - that make P. aeruginosa an important opportunistic pathogen? Its lack of endotoxin in cell walls helps it stay "invisible" to phagocytes It forms endospores It is common in its environmental reservoir It is resistant to many disinfectants and antibioticsPeople with AIDS are vulnerable to toxoplasmosis caused by theprotozoan Toxoplasma gondii, resulting in infection of lungs, liver,heart, and brain, and often leading to death. About 25% of the world’s population is infected, usually without developing symptoms. Why then are people with AIDS so susceptible to this disease?One of the most characteristic symptoms of malaria is the alternation of attacks (involving a cold phase, a hot phase, and a sweating phase) with periods of 1 or 2 days of no or few fevers. Given the life cycle of Plasmodium what is the best explanation for this pattern: When free in the blood, merozoites release chemicals that directly cause body responses. Merozoites appear in coordinated “waves”, which explains the cycling attacks Merozoites entering the red blood cells generate a strong response from the red blood cells, which stimulates a massive immune response Attack phase correlates with simultaneous bursting of infected red blood cells, releasing thousands or millions of merozoites. This triggers massive immune response, resulting in symptoms Plasmodium generates a constant accumulation of irritants in the blood, mostly residues from digesting hemoglobin . Once the amount reaches a critical level, these trigger a massive immune response
- How does Mycobacterium tuberculosis gain access through that preferred portal of entry Explain how the Mycobacterium tuberculosis is able to evade innate human host defenses that prevent this from occurring. discuss specific components of your pathogen. (Examples may include capsules, cell wall components, exoenzymes, antigenic variation and penetration of the host cell cytoskeleton.)A nurse is volunteering with a medical team in Southeast Asia. A 35-year-old female presents to the clinic reporting that the village doctors have diagnosed her with malaria. The nurse notes that the woman is febrile, tachypneic, and her eyes have a yellow tint. She reports generalized body aches and weakness. Through a translator, the nurse collects the woman's medical history. She reports feeling ill for about ten days, experiencing several cycles of fever, sweating, and chills that are temporarily relieved before occurring again. The village doctors treated her with a combination of a mosquito paste and an indigenous root, but her symptoms have not improved. The medical team performs serological testing at the clinic and confirms a diagnosis of malaria. 6) What is the cause of the cyclical nature of the woman's symptoms? A) She is being reinfected by a vector as she begins to recover. B) The village doctor's treatments are working intermittently. C) Her symptoms reflect the…A nurse is volunteering with a medical team in Southeast Asia. A 35-year-old female presents to the clinic reporting that the village doctors have diagnosed her with malaria. The nurse notes that the woman is febrile, tachypneic, and her eyes have a yellow tint. She reports generalized body aches and weakness. Through a translator, the nurse collects the woman's medical history. She reports feeling ill for about ten days, experiencing several cycles of fever, sweating, and chills that are temporarily relieved before occurring again. The village doctors treated her with a combination of a mosquito paste and an indigenous root, but her symptoms have not improved. The medical team performs serological testing at the clinic and confirms a diagnosis of malaria. 6) What is the cause of the cyclical nature of the woman's symptoms? A) She is being reinfected by a vector as she begins to recover. B) The village doctor's treatments are working intermittently. C) Her symptoms reflect the…
- Candida Albicans may cause minor infections in healthy people,but causes dangerous infections in immunocompromisedpatients. Why?Show a diagram showing the process of Mycobacterium tuberculosis on a cellular levelA 9 year old boy with cystic fibrosis – a genetic disease that causes a number of problems, including the build-up of thick sticky mucus in the lungs- complained of increasing fatigue, shortness of breath and worsening cough. When his mother took him to the doctor, she mentioned that his cough was a blue green color. His doctor immediately suspected a lung infection by Pseudomonas aeruginosa a common complication of cystic fibrosis. A sputum was collected and sent to the clinical laboratory. In the Clinical laboratory, the sample was plated onto Mac Conkey agar and blood gar and incubated. Mucoid colonies surrounded by bluish green color grew on both types of agar media. The colonies on Mac Conkey had no pink coloration, so the medical technologist concluded that the cells did not ferment lactose. She noted that the blue green color on the agar plates and in the sputum, knowing that P.aeruginosa makes several pigmented compounds that give rise to colors ranging from yellow to blue. One…