hm-dCDP ACTP ATCGTACIGCA ATP NDP kinase H,0 PP; TAGCATGACGI (host cell enzyme) Cytosine-containing DI ADP dСТРase DNases hm-dCTP ACMP DNA polymerase hm-Cytosine 5,10-CH,-THF DCMP hydroxymethyltransferase ATHGTAHIGHAG THE TAGHATGAHGTH hm-Cytosine-containing DNA NH2 CH,OH UDP-glucose a- and B-glucosyltransferases UDP Glucosyl- hm-cytosine N. deoxyribose P. ATHGTAHIGHAG TAGHATGAHGTH hm-dCMP g ATP Deoxyribonucleoside monophosphate kinase Glucosylated DNA A FIGURE 19.22 Metabolic pathways leading to nucleotide modifica- tions in E. coli infected by phages T2, T4, or T6. Virus-coded enzymes are shown in red. hm, hydroxymethyl. ADP

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Chapter4: Cell Structure
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Problem 43CTQ: Pathogenic E. coil have recently been shown to degrade tight junction proteins during infection. How...
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Refer to Figure , which describes the base modifications of bacteriophage T4 DNA, and briefly describe some issues that must be dealt with in preparing a restriction map of T4 DNA.

hm-dCDP
ACTP
ATCGTACIGCA
ATP
NDP kinase
H,0
PP;
TAGCATGACGI
(host cell enzyme)
Cytosine-containing DI
ADP
dСТРase
DNases
hm-dCTP
ACMP
DNA polymerase
hm-Cytosine
5,10-CH,-THF
DCMP
hydroxymethyltransferase
ATHGTAHIGHAG
THE
TAGHATGAHGTH
hm-Cytosine-containing DNA
NH2
CH,OH
UDP-glucose
a- and B-glucosyltransferases
UDP
Glucosyl-
hm-cytosine
N.
deoxyribose
P.
ATHGTAHIGHAG
TAGHATGAHGTH
hm-dCMP
g
ATP
Deoxyribonucleoside
monophosphate kinase
Glucosylated DNA
A FIGURE 19.22 Metabolic pathways leading to nucleotide modifica-
tions in E. coli infected by phages T2, T4, or T6. Virus-coded enzymes
are shown in red. hm, hydroxymethyl.
ADP
Transcribed Image Text:hm-dCDP ACTP ATCGTACIGCA ATP NDP kinase H,0 PP; TAGCATGACGI (host cell enzyme) Cytosine-containing DI ADP dСТРase DNases hm-dCTP ACMP DNA polymerase hm-Cytosine 5,10-CH,-THF DCMP hydroxymethyltransferase ATHGTAHIGHAG THE TAGHATGAHGTH hm-Cytosine-containing DNA NH2 CH,OH UDP-glucose a- and B-glucosyltransferases UDP Glucosyl- hm-cytosine N. deoxyribose P. ATHGTAHIGHAG TAGHATGAHGTH hm-dCMP g ATP Deoxyribonucleoside monophosphate kinase Glucosylated DNA A FIGURE 19.22 Metabolic pathways leading to nucleotide modifica- tions in E. coli infected by phages T2, T4, or T6. Virus-coded enzymes are shown in red. hm, hydroxymethyl. ADP
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