72.4.1 Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m), and you begin to ponder the "big questions," such as, "What is the fractional saturation of theDalai Lama's hemoglobin?"Part A-Assuming the Dalai Lama's hemoglobin has a Hill coefficient = 3.2, and a P50 = 31 mm Hg, calculate the change in fractional O2 saturation of his hemoglobingoing from his lungs (where Po₂ 90 mm Hg) to his capillaries (where Po₂ = 20 mm Hg).Express your answer using two significant figures.ΔΥΟ,=Submit—| ΑΣΦRequest AnswerReview | Constants | Periodic Table=?

Fractional Saturation (θ) is the fraction of protein molecules saturated with ligands. (since it is…

Answered: Suppose you visit the Dalai Lama in…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

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Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m),and you begin to ponder the “big questions,” such as “What is the fractionalsaturation of the Dalai Lama’s hemoglobin?”(a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2,and a P50 = 31 mm Hg, calculate the change in fractional O2 saturationof his hemoglobin going from his lungs (where PO2 = 85 mm Hg) to hiscapillaries (where PO2 = 25 mm Hg).(b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher thannormal (where “normal” = 27 mm Hg)?
Suppose you visit the Dalai Lama in Dharamsala, India (elevation 1460 m), and you begin to ponder the “big questions,” such as “What is the fractional saturation of the Dalai Lama’s hemoglobin?” a) Assuming the Dalai Lama’s hemoglobin has a Hill coefficient = 3.2, and a P50 = 31 mmHg, calculate the change in fractional O2 saturation of his hemoglobin going from his lungs (where PO2 = 85 mmHg) to his capillaries (where PO2 = 25 mmHg). b) Why do you suppose the Dalai Lama’s hemoglobin has a P50 higher than normal (where “normal” = 27 mmHg)?
Suppose Gina climbs a high mountain where the oxygen partial pressure in the air decreases to 70 torr. Assume that the pH of her tissues and lungs is 7.4 and the oxygen concentration in her tissues is 20 torr. The P50 of hemoglobin is 26 torr. The degree of cooperativity of hemoglobin, n, is 2.8. Estimate the percentage of the oxygen-carrying capacity that she utilizes. Calculate your answer to one decimal place. сараcity: %
Below is a fractional saturation curve for O₂ binding to adult hemoglobin. Assume that curve Y represents a condition at pH 7.4 and with a normal physiological level of 2,3-BPG. Curve X represents a condition that Fractional saturation (0) 0.2 0.0 0 Tissue PO, (kPa) 12 Lungs
o Suppose Gina climbs a high mountain where the oxygen partial pressure in the air decreases to 70 torr. Assume that the pH of her tissues and lungs is 7.4 and the oxygen concentration in her tissues is 20 torr. The P50 of hemoglobin is 26 torr. The degree of cooperativity of hemoglobin (n) is 2.8. Estimate the percentage of the oxygen-carrying capacity that she utilizes. oxygen-carrying capacity utilized: After Gina spends a day at the mountaintop, where the oxygen partial pressure is 70 torr, the concentration of 2,3-bisphosphoglycerate (2,3-BPG) in her red blood cells increases. Why does increasing the concentration of 2,3-BPG in Gina's blood cells help her function well at high altitudes? The P50 value of her hemoglobin increases, promoting oxygen delivery to tissues. The P50 value of her hemoglobin decreases, causing more blood-to-tissue oxygen offloading. The extra 2,3-BPG stabilizes the relaxed, or R, state of hemoglobin, increasing oxygen binding. Excess 2,3-BPG binds oxygen…
(b) The diagram on the right illustrates the change in the p50 (partial pressure of O2 required to achieve 50% saturation) of hemoglobin and the 2,3-bis-phosphoglycerate (BPG) concentration in the erythrocytes of a person who spent 6 days hik- ing in the Andes Mountains of Peru. As the hiker climbs to higher and higher altitudes, the atmos- pheric pressure, including the partial pressure of O2, decreases. Yet the p50 increases, making it less favorable to achieve saturation of the hemo- globin. Explain. Pso (torr) Sea level 34 33- 32 31 30- 29 28 27 26 4530 m above- sea level (c) If individuals with the following mutant hemo- globins accompanied the hiker, evaluate the degree of respiratory distress that they would experience despite the increased erythrocyte BPG concentration. (In the ta- ble of mutants on the right, the mutation His(143)Asp, for instance, means that the His residue that occurs at se- quence position 143 on the ß-chain has been substituted by Asp.) Describe the…
After spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?
Name 3 conditions (ex: pO2) in which the oxygen dissociation curve will shift to the left. Additionally, when there is such a shift to the left, does that mean that hemoglobin's affinity for O2 has increased or decreased?
The arterial O₂ concentration is given by the following expression [0₂] = 0.003 P0₂ + (PO₂)².8 +(26) 2.8 1. ЗЧНЬ (Рог ) 2-8 Where Poz is the alveolar O₂ pressure and Hb is the hemoglobin concentration in g/dL, respectively A subject who is at 0-95 ATM (211-0₂) has an arterial O₂ concentration of 19ml/dL and and arterial CO₂ pressure of 38mm Hg. Also, VO₂ = 340mL/min.; VCD₂ = 289 mL/min. Therefore, your hemoglobine level is: A. 14.39 Idl 8. 14.8 g/dl C. 15.2 g/dl D. 15.7g/dL E. 16 g/dL
(b) The diagram on the right compares O2-dissoci- ation curves for human hemoglobins characterized by dif- ferent p50 values. If Ko2 represents the equilibrium disso- ciation constant for oxygen binding, e.g., Hb(02)n Hb + nO₂ show the relationship between Ko2 and p50. Assign one of the curves (a, b, e) that best approxi- mates the Ko2 of each of the mutant hemoglobins in the table above including HbA where Ko2 represents the equi- librium dissociation constant for oxygen binding. If no curve is present for any of the mutant hemogobins, state the rea- son why the mutant is not represented. Indicate on the graph where its p50 would lie. PERCENT SATURATION 100- 80- 60- 40- 20- PARTIAL PRESSURE OF OXYGEN lungs veins muscle 0- 0 20 bc/d T 100 120 140 40 60 80 OXYGEN PRESSURE (millimeters of mercury) (c) Of the mutant hemoglobins in the table above, which form a hydrogen bond stabilizing the R (oxy) conformation similarly to that in wild type HbA. Justify this statement on the basis of the…
Precise data have been obtained for the oxygen binding of stripped human hemoglobin at 25 °C: Poz (mm Hg) Poz (= 100 x Yo,) (mm Hg) % Saturation % Saturation (= 100 × Y) 0.10 0.315 5.75 76.0 0.350 0.990 7.94 90.9 0.794 3.06 12.88 96.9 1.748 9.09 29.51 99.0 2.884 24.0 67.60 99.7 4.467 50.0
Carbon monoxide (CO) is a colorless, odorless gas produced during combustion of fuels (for example, by car engines and furnaces). The following graph depicts an oxygen dissociation curve in the absence and presence of varying amounts of carbon monoxide. Based on these results, in the presence of 20% CO, when PO2 is 90mmHg you should expect each hemoglobin molecule to have _____ molecule(s) of O2 bound a) 1 b) 2 c) 3 d) 4

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