BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Chapter 10.7, Problem 1LO
Summary Introduction
To distinguish: Proto-oncogenes and tumor suppressor gene.
Introduction: Cancer is an unrestrained and uncontrolled growth of cells in animals and humans. The disease initiated when suddenly the healthy cells start to grow in an uncontrolled manner.
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Distinguish between proto-oncogenes and tumor suppressor genes?
Define oncogene, proto-oncogene, and tumor-suppressor gene.
Distinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.
Chapter 10 Solutions
BIOLOGY
Ch. 10.1 - Prob. 1LOCh. 10.2 - Prob. 1LOCh. 10.2 - Distinguish between homologues and sister...Ch. 10.2 - Prob. 3LOCh. 10.3 - Describe the eukaryotic cell cycle.Ch. 10.4 - Prob. 1LOCh. 10.4 - Prob. 2LOCh. 10.5 - Describe the phases of mitosis.Ch. 10.5 - Explain the importance of metaphase.Ch. 10.5 - Compare cytokinesis in plants and animals.
Ch. 10.6 - Prob. 1LOCh. 10.6 - Prob. 2LOCh. 10.7 - Prob. 1LOCh. 10.7 - Prob. 2LOCh. 10 - Binary fission in prokaryotes does not require the...Ch. 10 - Chromatin is composed of a. RNA and protein. b....Ch. 10 - What is a nucleosome? a. A region in the cells...Ch. 10 - What is the role of cohesin proteins in cell...Ch. 10 - The kinetochore is a structure that functions to...Ch. 10 - Separation of the sister chromatids occurs during...Ch. 10 - Why is cytokinesis an important part of cell...Ch. 10 - What steps in the cell cycle represent...Ch. 10 - Cyclin-dependent kinases (Cdks) are regulated by...Ch. 10 - Prob. 2ACh. 10 - Genetically, proto-oncogenes act in a dominant...Ch. 10 - The metaphase to anaphase transition involves a....Ch. 10 - The main difference between bacterial cell...Ch. 10 - In animal cells, cytokinesis is accomplished by a...Ch. 10 - Regulation of the cell cycle is very complex and...Ch. 10 - Review you knowledge of signaling pathways...Ch. 10 - Compare and contrast how mutations in cellular...
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- Explain the difference between a proto-oncogene and a tumor suppressor gene.arrow_forwardDefine tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forwardDefine tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?arrow_forward
- Explain the difference between a proto-oncogene and a tumor-suppressor gene.arrow_forwardHow tumor-suppressor genes contribute to cancer whenmutated or abnormally expressed ?arrow_forwardExplain Mutations in tumor-suppressor genes are recessive at the cellular level but dominant at the organismal level.arrow_forward
- What is a primary function of tumor suppressor genes?arrow_forwardHow can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?arrow_forwardExplain about the TP53 Tumor-suppressor Gene ?arrow_forward
- Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancerarrow_forwardWhat are Tumor-suppressor genes ?arrow_forwardExplain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and how might gene therapy or other drug interventions inhibit the growth of a tumor?arrow_forward
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