Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 11.2, Problem 4R
Summary Introduction
To analyze:
The implication of the presence of p16 protein in the cells of the old people and aging.
Introduction:
p21 is a protein that is involved in regulating the G (gap) 1 checkpoint. When the DNA (deoxyribonucleic acid) in the cell is damaged, it leads to the production of p21 protein. This protein interacts with the G1-S (synthesis) Cdk, thereby, preventing the binding of the cyclin protein. The inactivated Cdk then leads to the halting of the cell cycle for repair. When the damage is more, the cell undergoes apoptosis. The protein p21 is similar to the p16 protein and have the similar function. The p16 protein is more in the old people than in the young people.
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Students have asked these similar questions
Cell division cycle mutations render the mutants unable to continue the cell cycle. This
phenotype creates a paradox where mutant cells must also be grown in the lab to further
identify the gene and study the role of the protein. How do you think this problem can be
solved?
You are studying three proteins that you think are important Yor progression through
the cell cycle.
You know that one of them is a phosphatase (P1) and the other two are kinases ( K1
and K2).
You add these enzymes in different combinations as shown below, and find that they
have different effects on the activity of a cyclin dependent kinase, cdk2p.
cdk2p
Inactive
Active
cdk2p + K1
cdk2p + K2
Inactive
cdk2p + K1 + K2
Inactive
cdk2p + P1
cdk2p + P1 + K2
cdk2p + P1 + K1
Inactive
Inactive
Active
cdk2p + P1 + K1 + K2
Active
1. (a) Describe the generalized model of the cell cycle. Demonstrate how cyclins and cyclin-dependent kinases can regulate the cell cycle.
(b). Describe three ways in which cells lose their ability to regulate their growth to become cancerous.
Chapter 11 Solutions
Life: The Science of Biology
Ch. 11.1 - Prob. 1RCh. 11.1 - Prob. 2RCh. 11.1 - Prob. 3RCh. 11.2 - Prob. 1RCh. 11.2 - Prob. 2RCh. 11.2 - Prob. 3RCh. 11.2 - Prob. 4RCh. 11.3 - Prob. 1RCh. 11.3 - Prob. 2RCh. 11.3 - Prob. 3R
Ch. 11.3 - Prob. 4RCh. 11.3 - Prob. 5RCh. 11.4 - Prob. 1RCh. 11.4 - Prob. 2RCh. 11.4 - Prob. 3RCh. 11.4 - Prob. 4RCh. 11.5 - Prob. 1RCh. 11.5 - Prob. 2RCh. 11.5 - Prob. 3RCh. 11.5 - Prob. 4RCh. 11.6 - Prob. 1RCh. 11.6 - Prob. 2RCh. 11.6 - Prob. 3RCh. 11.7 - Prob. 1RCh. 11.7 - Prob. 2RCh. 11.7 - Prob. 3R
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