Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 16, Problem 14RQ
A scientist compares the promoter regions of two genes. Gene A’s core promoter plus proximal promoter elements encompasses 70bp. Gene B’s core promoter plus proximal promoter elements encompasses 250bp. Which of the scientist’s hypotheses is most likely to be correct?
- More transcripts will be made from Gene B
- Transcription of Gene A involves fewer transcription factors
- Enhancers control Gene B’s transcription
- Transcription of Gene A is more controlled than transcription of Gene B.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Cancer cells were characterized for their high transcriptional and translational levels. Direct modification for the gene of interests during transcription could be complicated and troublesome. Moreover, simply knocked down a certain gene could stimulate other compensating pathways. Fortunately, there are many controls for gene transcription. Modifying on these controls mechanisms could be easier and more effective compared to changing the gene of interests directly. If you are working in a biotech company, please suggest three possible sites/targets to modify in order to decrease a certain gene transcriptional level in cancer cell.
Regulation of transcription is mediated by proteins that first must bind to specific sequences/elements that are present in DNA. Fill in the table below based on your knowledge of the different sequences and proteins involved in the regulation of eukaryotic gene expression.
Regulatory sequence
Category of Protein that Binds
Effect on Transcription of Associated Gene
Generic or Gene-Specific Regulation?
Core Promoter Element
Activator
Silencer
Shown below is the genomic structure of the human B-globin
gene. The numbers within the boxes indicate the length in
nucleotides of each region.
= exons
Transcription termination
site (also poly A site)
= introns
Promoter
Start of transcription
3'
5'.
TAA
ATG
50
TAC
130
222
850
126
132
90
ATT
5'
3
QUESTION 3: What is the length in nucleotides
of the mature, processed B-globin mRNA?
A.620
B.980
C.438
D.1600
Chapter 16 Solutions
Biology 2e
Ch. 16 - Figure 16.5 In E. coli, the tip operon is on by...Ch. 16 - Figure 16.7 In females, one of the two X...Ch. 16 - Figure 16.13 An increase in phosphorylation levels...Ch. 16 - Control of gene expression in eukaryotic cells...Ch. 16 - Post-translational control refers to: regulation...Ch. 16 - How does the regulation of gene expression support...Ch. 16 - If glucose is absent, but so is lactose, the lac...Ch. 16 - Prokaryotic cells lack a nucleus. Therefore, the...Ch. 16 - The a/a operon is an inducible operon that...Ch. 16 - What are epigenetic modifications? the addition of...
Ch. 16 - Which of the following are true of epigenetic...Ch. 16 - The binding of _____ is required for transcription...Ch. 16 - What will result from the binding of a...Ch. 16 - A scientist compares the promoter regions of two...Ch. 16 - Which of the following are involved in post...Ch. 16 - Binding of an RNA binding protein will the...Ch. 16 - An unprocessed pre-mRNA has the following...Ch. 16 - IS. Alternative splicing has been estimated to...Ch. 16 - Post-translational modifications of proteins can...Ch. 16 - A scientist mutates elF-2 to eliminate its GTP...Ch. 16 - Cancer causing genes are called transformation...Ch. 16 - Targeted therapies are used in patients with a set...Ch. 16 - Name two differences between prokaryotic and...Ch. 16 - Describe how controlling gene expression will...Ch. 16 - Describe how transcription in prokaryotic cells...Ch. 16 - What is the difference between a repressible and...Ch. 16 - In cancer cells, alteration to epigenetic...Ch. 16 - A scientific study demonstrated that rat mothering...Ch. 16 - Some autoimmune diseases show a positive...Ch. 16 - A mutation within the promoter region can alter...Ch. 16 - What could happen if a cell had too much of an...Ch. 16 - A scientist identifies a potential transcription...Ch. 16 - Describe how RBPs can prevent miRNAs from...Ch. 16 - How can external stimuli alter...Ch. 16 - Protein modification can alter gene expression in...Ch. 16 - Alternative forms of a protein can be beneficial...Ch. 16 - Changes in epigenetic modifications alter the...Ch. 16 - A scientist discovers a virus encoding a Protein X...Ch. 16 - New drugs are being developed that decrease DNA...Ch. 16 - How can understanding the gene expression pattern...
Additional Science Textbook Solutions
Find more solutions based on key concepts
Does the work you do on a book when you lift it onto a shelf depend on the path taken? On the time taken? On th...
College Physics
Define histology.
Fundamentals of Anatomy & Physiology (11th Edition)
1. Which trophic level(s) must be present to sustain any ecosystem?
a. producers only
b. producers and consume...
Biology: Life on Earth (11th Edition)
EVOLUTION CONNECTION The percentages of naturally occurring elements making up the human body (see Table 2.1) a...
Campbell Biology (11th Edition)
EVOLUTION CONNECTION Describe how gene flow, genetic drift, and natural sclection all can influence macroevolut...
Campbell Biology (10th Edition)
QUANTITATIVE Punnett Squares as Genetic Tools. The genetic characters of seed color (where Y is the allele for ...
Becker's World of the Cell (9th Edition)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Identify the statements that are features of a promoter. In prokaryotes, the promoter contains a −35 and −10 region upstream of the transcription start site. In prokaryotes, the promoter is recognized by general transcription factors (GTF), which recruit the RNA polymerase holoenzyme. In both prokaryotes and eukaryotes, the promoter is located in the 5' direction, upstream from the transcription start site. In eukaryotes, the promoter recruits the preinitiation complex, which includes the TATA-binding protein. In eukaryotes, the promoter attracts the small and large ribosomal subunits with the help of initiation factors.arrow_forwardWhich of the following statements about "Focused transcription initiation", "Dispersed transcription initiation" and "transcription start sites" (TSS) are correct. Note: it's more than 1! The majority of human genes is regulated from dispersed promoters. Focused initiation starts form a single or narrow set of transcription start sites (TSSS). Focused and dispersed transcription initiation refer to the extreme ends of a continuum of initiation patterns. O Dispersed transcription initiation is the evolutionary more ancient mechanism. RNA-seq is the preferred method to map TSS. Although dispersed promoter start from multiple TSS, the resulting transcripts usually encode for the same protein.arrow_forwardShown below is the genomic structure of the human B-globin gene. The numbers within the boxes indicate the length in nucleotides of each region. Question 6: How many amino acids are present in the wild-type human B-globin protein? = exons = introns Transcription termination site (also poly A site) Promoter Start of transcription 3' 5' ATG 50 TẠC TAA 126 132 |ATT 90 130 222 850 3 5' Start codon Stop codon А. 438 В. 146 C. 620 D. 206 © 2013 John Wiley & Sons, Inc. All rights reserved.arrow_forward
- The model below highlights the formation of condensates during transcription. Explain how such condensates can form and what their function may be. Enhancer Upstream DNA Transcription factor Transient gene-body condensate Dynamic promoter condensate Elongation and RNA processing factors Initiation factors and co-activators Pol II Downstream DNA Promoterarrow_forwardA TATA box is a short, A-T rich sequence of nucleotides located just upstream of genes and is used to recruit transcription factors and RNA polymerase to begin transcription. Based on this description, a TATA box is most likely a(n): promoter terminator transcription factor RNA polymerasearrow_forwardThe sigma factor protein's role in transcription in E. coli includes which of the following? None of the answer options are correct. plays a role in transcription termination forms part of the core enzyme required for transcription initiation helps the siRNA to bind to the promoter All of the answer options are correct. contributes to the proof-reading activity of RNA polymerase And The role of tRNA is to serve as an intermediate in the decoding of genes. serve as general translational components of the ribosome. facilitate protein trafficking in protein secretion. facilitate splicing of pre-messenger RNAs. act as vehicles bringing amino acids to the site of protein synthesis. None of the answer choices are correct.arrow_forward
- ennar region of gene X, which determines the length of the tail in mice, is mutated so that transcription factors bind it at a much higher affinity compared to the wild-type sequence. What is the most likely phenotypic outcome? Tail length will not change because the enhancer is a non-coding sequence Tail length will increased due to increased activity of the gene's promoter Tail length will decreased because any mutation will cause a loss-of-function of these regulatory regions Not just the tail will be enlarged because increased activity of the enhancer will impact many genesarrow_forwardYou are teaching a class on the regulation of eukaryotic gene expression. In order to demonstrate this complex process, you decide to draw for the class a typical eukaryotic gene/transcription unit with its major regions, such as the promoter regions, where the RNA polymerase II and transcription factors would bind From the list given - choose all components that you think are part of a typical eukaryotic gene From the list given - choose all the regulatory sequences that you think would control the expression of this eukaryotic gene From the list given - choose all of the regulatory proteins that would bind the eukaryotic gene to control its expressionarrow_forwardWhich of the following statements is false? a mutation in a 5' or 3' splice site must alter the sequence of the protein encoded by a gene a mutation in a transcriptional terminator is unlikely to alter the sequence of a protein encoded by a gene. a mutation in a promoter is unlikely to alter the sequence of the polypeptide encoded by a gene a missense mutations replaces one amino acid with a different amino acid a frameshift mutation changes the sequence of a protein 000 0arrow_forward
- Consider Figure 3, which shows some features of a eukaryotic gene. A, B, C are exons while 1, 2 are introns. E marks an enhancer. The 5’ UTR and 3’ UTR are also marked. Which one of the following features would you expect to NOT be included in the primary RNA (before any processing has occurred) that results from transcription of this gene? Region marked E Region marked 5’ UTR Regions marked A, B and C Regions marked 1 and 2arrow_forwardLack of phosporylation of the C-terminal domian of Pol Il will result in which of the following? O Assembly of the full set of general transcription factors plus Pol II at the promoter, but unphosphorylated Pol II cannot leave the promoter region No assembly of the general transcription factors at a promoter No binding of Pol II at a promoter The unphosphorylated Pol II can initiate and elongate but cannot terminatearrow_forwardThe following diagram show what is required for an active promoter of a gene of interest, where:A1 = Activator 1A2 = Activator 2Med = MediatorRep = Repressor Based on the following data, predict: Chromatin conformation Methylation state of the proximal promoter If protein A1 is present or absent If protein A2 is present or absent If the mediator is present or absent If the repressor is absence or present If this gene is likely to be transcribed or notPlease note that this is an "all or nothing" bonus question, and no partial credit will be awarded. Selecting all answers will result in zero points awarded. Selecting at least one incorrect answer will result in zero points being awarded. Question 28 options: Euchromatin Heterochromatin Methylated promoter Unmethylated promoter Activator A1 present Activator A1 absent Activator A2 present…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
QCE Biology: Introduction to Gene Expression; Author: Atomi;https://www.youtube.com/watch?v=a7hydUtCIJk;License: Standard YouTube License, CC-BY