Organic Chemistry (9th Edition)
9th Edition
ISBN: 9780321971371
Author: Leroy G. Wade, Jan W. Simek
Publisher: PEARSON
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Question
Chapter 21.7C, Problem 21.20P
(a)
Interpretation Introduction
Interpretation:
A mechanism corresponding to the hydrolysis of
Concept introduction:
The basic hydrolysis of an amide comprises of three steps. The first step is the addition of the nucleophile. The second step is the elimination of the leaving group. The third step is the proton transfer.
(b)
Interpretation Introduction
Interpretation:
A mechanism corresponding to the hydrolysis of
Concept introduction:
The mechanism of acidic hydrolysis of an amide comprises two stages. The first half is an acid catalyzed addition of the nucleophile (water). The second half is an acid catalyzed elimination of the leaving group.
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1. Biogenic Amines are inactivated primarily by
a. Sulfonation
b. Glucoronidation
c. Aromatic hydroxylation
d. Methylation
2. A drug can exert its pharmacological effect only if it is
a. Protein bound
b. Protein unbound
c. Free drug
d. Both B & C
e. Both A & C
3. In order for the drug to be ready and available for absorption, it must be release first from its dosage form with the exception of:
a. Capsule
b. Tablet
c. Solution
d. Suspension
4. All of the following are true, except
a. Solubility increase with decrease particle size
b. Solubility increase with increase surface area
c. Solubility increase with increase particle size
d. Solubility decrease with decrease surface area
5. The rate in which the drug appears in the bloodstream is also known as
a. Half-life
b. Potency
c. Bioavailability
d. Area under the curve
22. The stability of carbocation can be accounted by which of the following structural effect?
a. hyperconjugation
b. inductive effect
d. both a andb
C. resonance
23. Secondary amines are more basic than primary amines because of what structural effect?
a. hyperconjugation
b. inductive effect
C. resonance
d. steric effect
How could you convert N-methylbenzamide to the following compounds?
a. N-methylbenzylamine b. benzoic acid c. methyl benzoate d. benzyl alcohol
Chapter 21 Solutions
Organic Chemistry (9th Edition)
Ch. 21.2F - Name the following carboxylic acid derivatives,...Ch. 21.4A - Prob. 21.2PCh. 21.4A - Prob. 21.3PCh. 21.4A - Prob. 21.4PCh. 21.5C - Prob. 21.7PCh. 21.6 - When ethyl 4-hydroxybutyrate is heated in the...Ch. 21.6 - Propose a mechanism for the following ring-opening...Ch. 21.6 - Prob. 21.15PCh. 21.7B - Prob. 21.16PCh. 21.7C - Prob. 21.19P
Ch. 21.7C - Prob. 21.20PCh. 21.7C - Prob. 21.21PCh. 21.7D - Prob. 21.22PCh. 21.7D - The mechanism for acidic hydrolysis of a nitrile...Ch. 21.8A - Prob. 21.24PCh. 21.8C - Prob. 21.25PCh. 21.9 - Prob. 21.26PCh. 21.9 - Prob. 21.27PCh. 21.9 - Prob. 21.28PCh. 21.10 - Draw a mechanism for the acylation of anisole by...Ch. 21.10 - Prob. 21.30PCh. 21.11 - Prob. 21.31PCh. 21.11 - Prob. 21.32PCh. 21.12 - Problem 21-33 Propose a mechanism for the...Ch. 21.12 - Suggest the most appropriate reagent for each...Ch. 21.12 - Show how you would synthesize each compound,...Ch. 21.13 - Prob. 21.36PCh. 21.13 - Prob. 21.37PCh. 21.14 - Prob. 21.38PCh. 21.14 - Prob. 21.39PCh. 21.16 - Prob. 21.40PCh. 21.16 - Prob. 21.41PCh. 21 - Prob. 21.42SPCh. 21 - Give appropriate names for the following...Ch. 21 - Predict the major products formed when benzoyl...Ch. 21 - Predict the products of the following reactions....Ch. 21 - Prob. 21.46SPCh. 21 - Prob. 21.47SPCh. 21 - Prob. 21.48SPCh. 21 - Propose mechanisms for the following reactions.Ch. 21 - Prob. 21.51SPCh. 21 - An ether extraction of nutmeg gives large...Ch. 21 - Prob. 21.53SPCh. 21 - Show how you would accomplish the following...Ch. 21 - Prob. 21.55SPCh. 21 - Prob. 21.56SPCh. 21 - Prob. 21.57SPCh. 21 - Prob. 21.58SPCh. 21 - Prob. 21.59SPCh. 21 - Explain this curious result. What does this...Ch. 21 - Prob. 21.61SPCh. 21 - Prob. 21.62SPCh. 21 - Prob. 21.63SPCh. 21 - A chemist was called to an abandoned aspirin...Ch. 21 - Prob. 21.67SPCh. 21 - The IR spectrum, 13ONTVTR spectrum, and 1HNMR...Ch. 21 - Prob. 21.69SPCh. 21 - Prob. 21.70SPCh. 21 - Prob. 21.71SP
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