Life: The Science of Biology
Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 44.1, Problem 1R
Summary Introduction

To review:

The conduction of a signal between two neurons at a chemical synapse with the help of a diagram.

Introduction:

Each and every stimulus is carried to our brain by the sensory neurons. The stimulus is converted into the action potentials that are carried in the form of either an electrical impulse or the chemical message. The chemical message is transferred with the help of neurotransmitters like acetylcholine, glycine, and glutamine.

Life: The Science of Biology, Chapter 44.1, Problem 1R

Structure of two neurons representing the chemical synapse between them

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Parkinson's Disease Parkinson's disease is neurodegenerative disorder that affects movement. Most people affected with Parkinson's disease demonstrate rigidity, slow movement, and shaking. The symptoms of Parkinson's disease occur when the cells that produce dopamine neurotransmitters die in the brain.  Explain how the signal transmission at a synapse in an individual with Parkinson's disease is different than an unaffected individual.  Describe the normal process of signal transmission at a synapse.   Start with the arrival of an action potential at the axon terminal and include the name of the neurotransmitter that is affected by Parkinson's disease.   Explain how the process is different in individuals affected with Parkinson's disease.
When an impulse arrives at the synapse, the synaptic vesicles open and release neurotransmitters into the cleft within a thousandth of a second. Within another ten thousandth of a second, these molecules have diffused across the cleft and bound to receptor sites in the effector cell. In what two ways is transmission across a synapse terminated so that the neuron’s signal is concluded?
Draw a chain of two neurons that synapse on one another in sequence. Label the presynaptic and postsynaptic ends of each neuron, the cell bodies, dendrites, axons, axon hillock and axon terminals, location of voltage gated Ca²+ channels, location of voltage gated Na+ channels, location of voltage gated K* channels, location of Na*/ K+ pumps, location of neurotransmitter storage, location of neurotransmitter receptors. Consider your drawing and describe the function of neurons. Include an explanation why neurons are considered polarized cells and how this relates to their function. (Polarized here is not referring to membrane potential as all cells have a membrane potential). This means you will need to explain the location of different channels in the neuron and the relationship of the channels to the function of a neuron.
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