Tissue Engineering in Replace of Organ Donation

Supporting detail 1: With the advent of organ transplantation more than thirty years ago, the human body has quickly created a demand for replacement parts.

The recovery period after large scale injuries could be shortened. The effects are analyzed in an article that states, “True healing could occur thanks to the cloning of their own cells to help the recovery process” (“Pros and Cons” 5). Basically, the process of cloning healthy cells could be used as an aid in replenishing damage of unhealthy cells. This process, if it were to be actualized, could help recovery progress in anything from pulled muscles to the paralysis of an entire limb. In theory, the same research can be applied in other areas. If this technology is paired with stem cell research, it could result in a method of repairing physical damage. An article that focused on advances in biotechnology stated that “Another use of cloned stem cells could be the growth of replacement tissues in the laboratory” (LaPensee 15). Necrosis, apoptosis, and lymphocyte diapedesis all cause tissue damage or death. These tissues could be replaced by cloned cells of healthy tissues. This shortens recovery periods and leads to healthier tissue growth.

I watched Anthony Atala’s speech “Growing new organs” in TED Talks, and was convinced by Anthony that even engineered organ was very a controversial topic, it still brought benefits to patients who need tissue replacement. Anthony’s strongest delivery attribute was his language choices. He opened his speech by showing a story and research statistics of organ transplantation. For example, he pointed out: “every 30 seconds, a patient dies form diseases that could be treated with tissue replacement.” Anthony used the story and number wisely because he caught my attention and brought my interest to his speech. Also, Anthony used examples and stories of his own experience as a surgeon and a researcher. He not only established his credibility, but

This new research uses the scaffolding technique combined with stem cells to grow a heart. The new breakthrough was made using poor quality donated hearts. There were first stripped of heart tissue, leaving only the scaffolding of the heart. All of the tissue must be gone so that a potential patient won't risk rejection.

There are two methods of cloning organs. One is by injecting a growth factor into the wound site, causing the patient's own cells to migrate and regenerate. The other method is to harvest donor cells and pack them into a three-dimensional polymer scaffold, which is molded into the desired shape. These cells replicate and then can be transplanted into a recipient. The polymer breaks down as the cells form into the shape desired. These organs are called neo-organs. While this may sound like something straight out of a science fiction film, like Dolly, neo-organs are already a reality. All over the United States, grown skin is being used to treat everything from burn victims to skin cancer patients. Also, machines containing cloned liver cells are being used to filter blood until a transplant can be found. Cartilage, because of it's relatively simple structure, seems likely to be the next step. Larger organs will take

Doctors and engineers have been working on another way to get organs a faster and more efficient way. Using 3D printers can help with their problem. They have worked on using a 3D printer to make organs that are a perfect match for patients. This can be very useful it can get an organ ready in a short amount of time helping the patient recovery faster as well. Organ transplants are hard to come by. One you have to be put in a waiting list, and people are usually on that list for a long while, just waiting for a perfect match to come. But sometimes it takes to long and some people die while still on the waiting list. But when an organ finally does come they feel bad because someone had to die in order for them to use it. So Dr Ali Khademhosseini is trying to use 3D printing to help solve this problem. His theory is he can make organs from a 3D printer, which can make the waiting list decrease faster and have people not have to die in order for a perfect match. 3D printers have been used to make Human cells, tissue, and blood vessels. But making something like a heart is much more difficult. Because you have to make the beating and pumps. (Mesley). There have been problems in the past that have just know started to show in some people. "Viruses aren't the only worry, and here too the past may serve as a guide. In 1956 injections of human growth hormone became a standard therapy for children failing to develop properly. The hormone was extracted from

In the past, the only way to replace diminished cells, tissues, and organs was from organ transplantation. An organ donor was needed, and the tissues would be surgically removed from the donated body and placed into the recipient. Due to the current research being conducted, it is believed that tissue engineering and organ printing can contribute to the process of improving and saving lives.

Thesis: Instead of waiting on a list to get an organ transplant, bio-medical engineers can grow an organ using your own cells. Introduction I. Attention Step: There are approximately 123,797 people waiting for an organ transplant in the U.S. Organs are only available when an organ donor dies or a living person donates one. 18 people die each day waiting for their organ.

My exploration of this topic led me to an article on HuffingtonPost.com. The article is “How 3D Printing Could End The Deadly Shortage of Donor Organs” by Macrina Cooper-White. In said article,

In the United States, 122,737 patients are on the United Network for Organ Sharing (UNOS) list that are in need of lifesaving organs. With the current UNOS system, nearly 3,300 patients are expiring every year waiting for kidney transplants, let alone the other organs needed (Foundation, 2014). The length of time and money the process takes to procure an organ from a cadaver could be nearly done away with using bioengineered organs rather than procurement. Forms of Bioengineering are done with the use of matrices alone in which the body’s natural regenerative properties correct the issue, or using matrices embedded with undifferentiated cells. With the use of Bioengineering organs of one’s own, stem cell onto matrices could reduce or eliminate the use of immunosuppressant. Bioengineering organs can change the health care by reducing the cost of care, shortening the wait for transplantation, and extending the life of the recipient. Results Many of the patients with end-stage organ failure were going untreated or minimal treatment due to the lack of insurance. In 2010 that changed when President Obama signed the health care reform act, which is expanding coverages and limiting the growth in health care cost while reforming the delivery and insurance system. Prior to the Health Care Reform Act, individuals, that had an illness could not change jobs due the fact of being ineligible for

Aside from these state level approaches, 3D printing offers a promise for increasing available organs. This promise was validated in 2016, when a toddler from Northern Ireland became the “first to have a life-saving adult kidney transplant, using 3D printing.” While much work still needs to be done, printed organs, in addition to other proposed solutions, are alternatives to creating human-pig chimeras for organ transplantation.

As today’s technology is changing, some of the most major effects of it are superior advances in the medical field. One advance in the medical field is tissue engineering. It is being developed for use in regenerative medicine and soon to be in wider use for other treatments. Tissue engineering’s goal for the future is for the medicine to be able to stimulate other cells around the damage area of the body to get them to grow and produce living tissue (Sciencedaily). Another medical advancement is the monitoring systems and how hospitals can better track for problems and signs of an emergency. This can also help the surgeons decide how to stitch up a patient for best recovery time (Sciencedaily). As technology keeps progressing, another medical advancement is the way surgeons are doing operations. Today, for complex surgeries, surgeons now will get help from the use of a robot for accurate procedures; this will help with the size of the incision and keep the recovery time shorter than during standard surgery.

In the article “The next frontier in 3-D printing: Human organs” written by Brandon Griggs, published by CNN on April 5, 2014, Griggs explains how the new technology in 3-D printing is progressing from printing “toys to jewelry to food” and now, still developing, human organs. Although it seems positive to patients who are waiting and in need of organs, there are still some heated discussions as to the responsibility of producing and guaranteeing quality the artificial organs. Another

Lately, there is an emerging innovation whereby organs are created to form and increase in size by a process of inorganic accretion, from the patient’s cell. This field of medicine is known as the regenerative medicine. In addition to this, there are basically various types of regenerative medical

By combining this technology with human cloning technology it may be possible to produce needed tissue for suffering people that will be free of rejection by their immune systems. Conditions such as Alzheimer’s disease Parkinson’s disease, diabetes, heart failure, and other problems may be made curable by human cloning. (“Cloning to Save Lives”)