This is a picture of the catalysis of alcohol by ADH with an inhibitor binding as an aldehyde analog. I have two questions. First, what would the enzyme be classified as and why? Also, what would the steps of this mechanism be?
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- 1. pH Effects a. In the enzyme mechanism of lysozyme, two acidic amino acid residues, Asp52 and Glu35, are critical for catalytic activity. If we assume normal side chain pKa values for Asp (pKar = 3.90) and for Glu (pKar = 4.07), what proportion of enzyme molecules will have both Asp52 and Glu35 in the correct ionization state at pH 5.0 (the pH optimum for lysozyme)? b. Are the traditional pKa values likely to be correct within the protein? What pKa changes might be present within lysozyme?His388 Glu357 His388 Glu357 Ring opening Proton HO HO abstraction HO но- G6P He NH- NH His388 His388 His388 Glu357 Glu357 Glu357 HO но HO но- но OH cis-enediol F6P Ring closure intermediate OH Describe the mechanism shown above for phosphoglucose isomerase. Describe the chemistry of each step • How the enzyme appears or might facilitate the chemistry How the enzyme increases the reaction rate.What is the catalytic efficiency of Catalase ? Table. The values of KM and kcat for some Enzymes and Substrates Enzyme Carbonic anhydrase Substrate CO2 HCO3 KM (M) 1.2 x 10-2 2.6 x 10-2 Kcat (s-1) 1.0 x 106 4.0 x 105 Catalase H2O2 2.5 x 10-2 1.0 x 107 Urease Urea 2.5 x 10-2 4.0 x 105 O A. 4 x 108 M-s-1 O B. 4 x 108 M-1.s-1 OC25x 10-9 M-s1 D. 2.5 x 102 M-1.s-1 OE 1.0 x 107 s1
- Handwritten Identify the molecule names, enzyme name, enzyme classification and change in reaction(for glycolysis pathway)The enzyme that catalyzes reaction below can be classified as: CoO COO NAD+ NADH + H* Но- | malate -C- H-Ć- dehydrogenase Охaloacetate Malate isomerase lyase hydrolase oxidoreductase ligase transferasePalmitoleic acid, 16:1Δ⁹ hexadecaenoic acid, (16 carbon FA with one double bond )is an important fatty acid component of TAGs and cell membranes. Briefly explain the process of beta oxidation of this fatty acid and the number (only) of FADH, NADH and acetyl CoA outcome. What is the total ATP (only number) generated from this fatty acid after beta oxidation.
- [AktivGrid] Draw the product of the reaction of isocitrate catalyzed by isocitrate dehydrogenase in the TCA (citric acid) cycle. Provide the structure in the protonation state found in physiological conditions. rxn' F-C-H NAD+ isocitra te dehydro genase NADH, Dra H+, > Problem 5 of 12 Submit H Atoms, Bonds and Rings OH Charges CH2OH Drag To Pan CH2OH- H OH Undo Reset ―CH2OH- Remove Done ⚫SH CHO +CHO CHO CH,OH HO- H Phosphorogluco- isomerase Phosphofructo- kinase Hexokinase но H. но -H- но H- HO- АТР ADP H- HO- -HO- OH H- OH H- OH Via H- -HO- ATP ADP CH2OH CH,OPO,2 ČH,OPO,2 Но nin Glucose A B CH,OPO,2- CH2OPO, Fructose Fo D CH2OH Но H- biphosphate H- HO. HPO,2 / NAD+ / Triose aldolase OH Glyceraldehyde 3- phosphate dehydrogenase phosphate isomerase CH,OPO,2 Via OPO,2 сно HOH E CH,OPO, H- OH LOH CH,OPO, For CH,OPO,2 G COPO,2 он H3C HO. Pyruvic AcidNH2 'N. NH NH NH2 Benzamidine and Leupeptin are competitive trypsin inhibitors. They are shown in their deprotonated forms at high pH. Modify the above drawings to show the protonation and charge at pH 7.0 Draw competitive inhibitors for chymotrypsin based on these structures IZ ZI ZI
- Lysozyme is a catalytic enzyme that cleaves NAG-NAM units in the bacte- rial cell wall, and is found in external secretions of the body. Why does thisNH2 Part A N- N. Which of the following is found in the coenzyme FAD? 'N Check all that apply. V two heterocyclic rings O ADP OH HO OH O a substituted benzene ring O a phosphate anhydride bond Submit Previous Answers Request Answer X Incorrect; Try Again; 6 attempts remaining NH Provide FeedbackThe conversion of glucose-6-phosphate to fructose-6-phosphate in the glycolytic pathway (Choose all that apply) O positions a carbonyl group on carbon 2 of fructose-1-phosphate O positions an amino group NH2 on carbon 3 of fructose-1-phosphate O positions a carbonyl group on carbon 3 of fructose-1-phosphate O is an aldose-keto isomerization O positions a primary alcohol function at carbon C-1 that facilitates phosphorylation of fructose-6-phosphate O is a keto-aldose isomerization O positions an amino group NH2 on carbon 2 of fructose-1-phosphate
