GK 4 G 2 1 2 3 4 5 6 7 8 N Bits

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 11CRQ
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Three polypeptides, the sequences of which are represented below using the one-letter code for their amino acids, are present in a mixture:
1. ATKNRASCLVPKHGALMFWRHKQLVSDPILQKRQHILVCRNAAG
2. GPYFGDEPLDVHDEPEEG
3. PHLLSAWKGMEGVGKSQSFAALIVILA
Of the three, which one would migrate most slowly during chromatography through:
(a) an ion-exchange resin, beads coated with positively charged groups?
(b) an ion-exchange resin, beads coated with negatively charged groups?
(c) a size-exclusion (gel-filtration) column designed to separate small peptides such as these?
(d) Which peptide contains the ATP-binding motif shown in the following sequence logo?

GK
4
G
2
1 2 3 4 5 6 7 8
N
Bits
Transcribed Image Text:GK 4 G 2 1 2 3 4 5 6 7 8 N Bits
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