Fundamentals of Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134396026
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Question
Chapter 16, Problem 31RQ
Summary Introduction
To determine:
The neurotransmitter to which the given molecule is mimicking and also the receptors to which it is binding.
Concept introduction:
The sympathetic nervous system releases norepinephrine as neurotransmitter at the target organs and tissues, to produce the desired physiological effects. The norepinephrine binds to adrenergic receptors on the plasma membrane and activates the G-protein. The G-protein then produces the effects through the second messengers and other intermediaries.
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When the neurotransmitter acetylcholine (ACh) binds the acetylcholine receptor (a GPCR) on muscle cells, it causes them to contract. ZIGGY, a chemical analog of ACh, also binds to the same acetylcholine receptor on muscle cells, but instead causes the muscle cells to relax. For this reason, it is sometimes prescribed as a muscle relaxer. Explain in 3-4 sentences how ZIGGY could cause muscle relaxation.
How can both ZIGGY and ACh bind the same GPCR? And then how can they have different effects on the cells, despite binding to the same receptor on the same cells?
Botox has become popular for reducing wrinkles. It is a dilute solution of a toxin which inhibits muscle contraction by working at the presynaptic portion of the NMJ. Which of the following could be a possible mechanism for Botox wrinkle-reducing action?
a.) Increase Calcium influx
b.) Cleave (degrade) syntaxin
c.) Increase sensitivity of synaptotagmin to Ca
d.) Decrease synthesis of nSec1
are these True or False?
Receptors on the post-synaptic cell membrane that bind the acetylcholine are voltage-gated channels (channels that open in response to a change in the electrical charge of the membrane).
When a muscle cell is not contracting its cell membrane is negative on the inner surface.
The effect of a neurotransmitter on the muscle cell membrane is to modify its ion permeability properties temporarily.
Chapter 16 Solutions
Fundamentals of Anatomy & Physiology (11th Edition)
Ch. 16 - Prob. 1CPCh. 16 - Prob. 2CPCh. 16 - Prob. 3CPCh. 16 - Prob. 4CPCh. 16 - Prob. 5CPCh. 16 - Prob. 6CPCh. 16 - Prob. 7CPCh. 16 - Prob. 8CPCh. 16 - Prob. 9CPCh. 16 - Prob. 10CP
Ch. 16 - Name the two types of cholinergic receptors on the...Ch. 16 - Prob. 12CPCh. 16 - Prob. 13CPCh. 16 - Prob. 14CPCh. 16 - Prob. 15CPCh. 16 - Prob. 16CPCh. 16 - Prob. 17CPCh. 16 - Prob. 18CPCh. 16 - Prob. 19CPCh. 16 - Prob. 20CPCh. 16 - Prob. 21CPCh. 16 - Prob. 22CPCh. 16 - Prob. 23CPCh. 16 - Prob. 24CPCh. 16 - Prob. 25CPCh. 16 - Prob. 26CPCh. 16 - Prob. 27CPCh. 16 - Prob. 28CPCh. 16 - Prob. 1RQCh. 16 - Prob. 2RQCh. 16 - Prob. 3RQCh. 16 - Prob. 4RQCh. 16 - Prob. 5RQCh. 16 - Prob. 6RQCh. 16 - Prob. 7RQCh. 16 - What are the components of a visceral reflex arc?Ch. 16 - Prob. 9RQCh. 16 - Prob. 10RQCh. 16 - Prob. 11RQCh. 16 - All preganglionic autonomic fibers release _____...Ch. 16 - Prob. 13RQCh. 16 - Prob. 14RQCh. 16 - Prob. 15RQCh. 16 - Prob. 16RQCh. 16 - Prob. 17RQCh. 16 - Prob. 18RQCh. 16 - Prob. 19RQCh. 16 - Prob. 20RQCh. 16 - Prob. 21RQCh. 16 - Prob. 22RQCh. 16 - Prob. 23RQCh. 16 - Prob. 24RQCh. 16 - Prob. 25RQCh. 16 - Prob. 26RQCh. 16 - Prob. 27RQCh. 16 - Prob. 28RQCh. 16 - Prob. 29RQCh. 16 - Prob. 30RQCh. 16 - Prob. 31RQCh. 16 - Prob. 1CCCh. 16 - Prob. 2CCCh. 16 - Prob. 3CC
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- A researcher is investigating the effects of a toxin, isolated from the skin of a South American tree frog. The researcher is exploring the effect of that toxin on synaptic transmission at the mammalian skeletal neuromuscular junction. Their previous studies established that the toxin had no direct effect upon skeletal muscle contractility, but it did block muscle contractility elicited indirectly via electrical stimulation of the motor nerve. To establish how the toxin influenced synaptic transmission, in vitro studies were performed using the mouse phrenic nerve hemidiaphragm skeletal muscle preparation, bathed in a buffered saline solution containing a raised magnesium and lowered calcium concentration. Under these conditions intracellular recording determined the effect of the toxin on the amplitude (in mV) of miniature endplate potentials (mepps) and endplate potentials (epps) – see Table 1. Mean mepp amplitude Mean epp amplitude Control 0.5 mV 8 mV Toxin 0.5 mV 2 mV Table 1: Mean…arrow_forwardIn the rare neuromuscular disorder Myasthenia Gravis, autoantibodies are produced which inhibit acetylcholine receptor (nicotinic receptor) activity. Explain how inhibition of acetylcholine receptor activity at the neuromuscular junction will affect the sequence of events in muscular excitation and contraction in response to stimuli, and muscle function? (Mention the effects on all the significant events involved in excitation and contraction of muscles, and how it would affect muscle function).arrow_forwardPlease fill in the blanks: A(n) ["action potential", "muscle twitch", "contraction"] consists of a wave of depolarization that moves along the plasma membrane of a neuron or a muscle fiber. This wave of depolarization is immediately followed by repolarization. Depolarization is when the cell's membrane potential becomes more ["resting", "negative", "positive"] . Depolarization occurs when calcium channels open in the plasma membrane. Repolarization is when the cell's membrane potential becomes more ["resting", "positive", "negative"] , returning the cell to its resting potential. Repolarization occurs when ["calcium", "sodium", "potassium"] channels close and ["sodium", "calcium", "potassium"] channels open.arrow_forward
- Curare is a dangerous poison extract from plants that can block the binding site of Acetylcholine receptor channels in neuromuscular junctions. Which of the following molecular events will curare directly inhibit or prevent from occurring? Action potential traveling down the sarcoplasmic reticulum End-plate potential forming Release of calcium ions from the sarcoplasmic reticulum Release of Acetylcholine from axon terminalsarrow_forwardWhich of the following statements about action potentials and information transmission in the synaptic cleft is FALSE? 1. Action potentials determine the amount of neurotransmitters that are released into the synaptic cleft 2.Action potentials ultimately result in more calcium leaving the target cell at the postsynaptic membrane 3. Action potentials determine the duration that neurotransmitters are released into the synaptic cleft 4. Action potentials ultimately result in more calcium entering the neuron at the axon terminalarrow_forwardWhich of the following is the role of axonal Calcium (Ca2+) channels in neuronal communication at the synapse? a) they inhibit the action potential causing it to stop b) Calcium channels have no role in this process c) by allowing calcium to exit the cell, they promote the propagation of action potential across the synapse by creating depolarization d) by blocking calcium entrance, they mediate the contraction of presynaptic axon to facilitate movement e) when they open, calcium enters the presynaptic terminal, promoting fusion of neurotransmitter vesicles with presynaptic membrane, and release of neurotransmitters to the synaptic cleftarrow_forward
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