Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 9, Problem 42SA
Summary Introduction
To review:
The deficiency of pyruvate carboxylase thatresults in lactic aciduria, an illness where lactate appears in the urine.
Introduction:
In all aerobic living organisms, the citric acid cycle or Kreb’s cycle is present in order to release the energy stored in a 2-carbon acetyl, that is, acetyl-CoA (Coenzyme A) by a series of biochemical reactions. This cycle occurs in the matrix region of mitochondria in a living cell. Acetyl-CoA is formed from the pyruvate in the process of glycolysis and in the catabolism of fatty acids.
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Chapter 9 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 9 - Prob. 1QCh. 9 - Prob. 2QCh. 9 - Prob. 3QCh. 9 - Prob. 4QCh. 9 - Prob. 5QCh. 9 - Prob. 6QCh. 9 - Prob. 7QCh. 9 - Prob. 1RQCh. 9 - Prob. 2RQCh. 9 - Prob. 3RQ
Ch. 9 - Prob. 4RQCh. 9 - Prob. 5RQCh. 9 - Prob. 6RQCh. 9 - Prob. 7RQCh. 9 - Prob. 8RQCh. 9 - Prob. 9RQCh. 9 - Prob. 10RQCh. 9 - Prob. 11RQCh. 9 - Prob. 12RQCh. 9 - Prob. 13RQCh. 9 - Prob. 14RQCh. 9 - Prob. 15RQCh. 9 - Prob. 16RQCh. 9 - Prob. 17RQCh. 9 - Prob. 18RQCh. 9 - Prob. 19RQCh. 9 - Prob. 20RQCh. 9 - Prob. 21RQCh. 9 - Prob. 22RQCh. 9 - Prob. 23RQCh. 9 - Prob. 24RQCh. 9 - Prob. 25RQCh. 9 - Prob. 26RQCh. 9 - Prob. 27RQCh. 9 - Prob. 28FBCh. 9 - Prob. 29FBCh. 9 - Prob. 30FBCh. 9 - Prob. 31FBCh. 9 - Prob. 32FBCh. 9 - Prob. 33FBCh. 9 - Prob. 34FBCh. 9 - Prob. 35FBCh. 9 - Prob. 36FBCh. 9 - Prob. 37FBCh. 9 - Prob. 38SACh. 9 - Prob. 39SACh. 9 - Prob. 40SACh. 9 - Prob. 41SACh. 9 - Prob. 42SACh. 9 - Prob. 43TQCh. 9 - Prob. 44TQCh. 9 - Prob. 45TQCh. 9 - Prob. 46TQCh. 9 - Prob. 47TQCh. 9 - Prob. 48TQCh. 9 - Prob. 49TQCh. 9 - Prob. 50TQCh. 9 - Prob. 51TQCh. 9 - Prob. 52TQCh. 9 - Prob. 53TQCh. 9 - Prob. 54TQCh. 9 - Prob. 55TQCh. 9 - Prob. 56TQCh. 9 - Prob. 57TQCh. 9 - Prob. 58TQCh. 9 - Prob. 59TQ
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- In what condition and why is pyruvate converted to lactate?arrow_forwardHow does the hydrolysis of fructose-1,6- bisphosphate bring about the reversal of one of the physiologically irreversible steps of glycolysis?arrow_forwardThe disease beriberi, which results from a dietary deficiency of vitamin B1 (thiamine), is characterized by neurologic and cardiac symptoms, as well as increased levels of pyruvate and a-ketoglutarate in the blood. How does a deficiency of thiamine account for the increased levels of pyruvate and a-ketoglutarate?arrow_forward
- Why are the enzymes α-Amylase and α-glucosidase active in a patient with hyperglycemia or diabetes? How do they become activated?arrow_forwardWhat is ornithine transcarbamylase (OTC)deficiency ?arrow_forwardName the molecules used for gluconeogenesis. What are the sources of these molecules? Under what conditions would gluconeogenesis occur?arrow_forward
- What is the effect on gluconeogenesis and glycogen synthesis of (a) increasing the level of ATP, (b) decreasing the concentration of fructose-1,6- bisphosphate, and (c) increasing the concentration of fructose-6- phosphate?arrow_forwardWhat is the role of pyruvate dehydrogenase and what are its products?arrow_forwardWhat is the rule of 2 for gluconeogenesis ?arrow_forward
- What are the diseases a-ketoglutarate dehydrogenase deficiency, succinate dehydrogenase deficiency, and fumarase deficiency? and why most of these disease clinical features of these diseases involve muscle and nerve tissue?arrow_forwardPyruvate dehydrogenase deficiency, a severe condition with a poor prognosis, results in neurological dysfunction and unremitting lactic acidosis. One treatment is placing the patients on a low carbohydrate/high fat diet. ( a) Explain why the deficiency would be characterized by neurological dysfunction. ( b) Why does lactic acidosis result? ( c) Explain the rationale for the low carbohydrate/high fat diet.arrow_forwardWhat is the name of the by-product of anaerobic glycolysis that can lead to muscle fatigue and why does this by-product cause muscle fatigue?arrow_forward
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